|
KMID : 0606920060140030125
|
|
Biomolecules & Therapeutics
2006 Volume.14 No. 3 p.125 ~ p.131
|
|
|
Inhibitory Effects of (-)-Epigallocatechin gallate on Morphine-Induced Locomotor Sensitization and Conditioned Place Preference in Mice
|
|
Eun Jae-Soon
Kwon Han-Na
Hong Jin-Tae
Oh Ki-Wan
|
|
|
Abstract
|
|
|
|
The inhibitory effects of (-)-epigallocatechin gallate (EGCG), a major compound of green tea, on the development of locomotor sensitization, conditioned place preference (CPP) and dopamine receptor supersensitivity induced by the repeated administration of morphine were investigated in mice. A single administration of morphine produces hyperlocomotion. The repeated administration of morphine develops sensitization, a progressive enhancement of locomotion, which is used as a model for studying the craving and drug-seeking behaviors characterizing addiction, and CPP, which is used as a model for studying drug reinforcement, respectively. EGCG inhibited morphine-induced hyperlocomotion, sensitization and CPP. In addition, EGCG inhibited the development of postsynaptic dopamine receptors supersensitivity, which may be an underlying common mechanism that mediated the morphine-induced dopaminergic behaviors such as sensitization and CPP. Apomorphine (a dopamine agonist)-induced climbing behaviors also were inhibited by a single direct administration of EGCG These results provide evidence that EGCG has anti-dopaminergic activity, as inhibiting the development of dopamine receptor supersensitivity and apomorphine-induced climbing behaviors. Therefore, it is suggested that green tea may be useful for the prevention and therapy of these adverse actions of morphine.
|
|
|
KEYWORD
|
|
|
(-)-Epigallocatechin gallate (EGCG), Morphine, Hyperlocomotion, Locomotor sensitization, Conditioned place preference (CPP), Dopamine receptor supersensitivity, Climbing behavior
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|